Error 6010 100 is a common QuickBooks issue that prevents users from opening their company file. It usually occurs when QuickBooks is disconnected from the Database Server Manager. Antivirus programs, corrupted installation files, or network issues often cause this problem. To fix it, first rename the network data files, then run the QuickBooks Database Server Manager to rescan company files. If the error continues, reinstalling QuickBooks in selective startup mode may resolve hidden software conflicts that are blocking file access.