Optimizing computational workflows using Nextflow on AWS Batch enables scalable, cost-efficient execution of data-intensive pipelines, especially in genomics and bioinformatics. Nextflow is a powerful workflow orchestration engine designed to manage complex pipelines by chaining multiple processes, handling dependencies automatically, and enabling parallel execution across large datasets. When combined with AWS Batch, organizations can run production-grade pipelines without managing infrastructure, as AWS handles compute provisioning, job scheduling, scaling, and monitoring.