Mitogen-Activated Protein Kinase 8 (MAPK8), commonly known as c-Jun N-terminal kinase 1 (JNK1), is an essential enzyme within the mitogen-activated protein kinase (MAPK) signaling pathway. This pathway is vital for regulating various cellular processes, including inflammation, apoptosis, cell proliferation, and the response to stress. MAPK8 becomes active in response to diverse external stimuli, such as cytokines, oxidative stress, ultraviolet radiation, and metabolic disturbances, highlighting its critical role in cellular adaptation and survival.