The cephalosporin drugs market represents an important segment of the global pharmaceutical industry, focusing on β-lactam antibiotics derived from Acremonium fungi. These drugs are used to treat large scale bacterial infections such as pneumonia, urinary tract infections, skin infections and respiratory tract infections. Cephalosporin is divided into five generations depending on their antimicrobial spectrum, exhibited increased activity against gram-negative bacteria with new generations and has better resistance to β-lactamases. Their extensive use in both human and veterinary medicine highlights their importance in dealing with infectious diseases worldwide.